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In male rats exposed to alcohol for long periods of time, acute treatment with either Ex-4, GLP-1, liraglutide or semaglutide reduces both the alcohol consumption and the preference for alcohol ( Taken together these preclinical studies show that GLP-1R activation is required for alcohol consumption, an effect persistent across species and GLP-1R agonists used

Katagiri, K., Matsuzawa, A

Enteric glia have been shown to exert beneficial effects in cellular or animal models of several neurological disorders, including spinal cord injury [30], Alzheimers disease (AD) [31], and multiple sclerosis [32]

It was also shown to ameliorate Alzheimers disease-related pathologies in several other rodent models of Alzheimers disease [R, R]