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It occurs endogenously in humans, where it has been identified in the hypothalamus, the limbic system, the pituitary, and even the gastrointestinal tract

doi: 10.3389/fvets.2023.1093274 Received 08 November 2022 Accepted 20 January 2023 Published 16 February 2023 Volume 10 - 2023 Edited by Ayman Abdel-Aziz Swelum, Zagazig University, Egypt Reviewed by Amany Abdel-Rahman Mohamed, Zagazig University, Egypt

Nowadays, drug resistance is a primary concern that restricts the application of sorafenib, and the average resistance impact lasts around a year

However, you should recognize the potential negative consequences of using it