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GLP-1R expression by immunohistochemical staining suggested that there was a marked increase in the expression in the PSCs, with activation (compare Figures 6a vs 6b)
However, when we look at just the first year, we did see an increase in risk
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These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)
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