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At LeanMD, Phase 1 typically runs 212 months, after which medication is tapered during the transition phase as sustainable habits take over
The combined effect creates a metabolic state where appetite is significantly reduced, gastric emptying is slowed (meaning food stays in the stomach longer and meals feel more satisfying), insulin dynamics are optimized for fat mobilization rather than fat storage, and resting energy expenditure is elevated through glucagon-mediated thermogenesis
Beyond glucose control, GLP-1 medications influence several pathways that affect cardiometabolic health
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