For randomized controlled trials, the Cochrane RoB 2.0 tool was applied across seven domains: random-sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other sources of bias
The appetite suppression, weight loss, and other benefits become more pronounced once steady-state concentrations are achieved
5 Monitor Progress Follow-up may track weight trend, waist measurement, blood pressure, glucose, bowel symptoms, hydration, protein intake, strength, adverse effects, and adherence
The benefits exceed what would be expected from glucose control alone, suggesting direct protective effects beyond metabolic improvement