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Read On When a person ages, the skin loses its elasticity and volume with marked fine lines and wrinkles in place
Due to prolonged exposure to oxidative stress during the prenatal period, it is postulated that a decline in the compensatory antioxidant capacity of cells may exacerbate oxidative-related comorbidities, including cognitive phenotypes
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281 Importantly, while acute or overwhelming endoplasmic reticulum stress can induce cell death, chronic UPR activation favors drug tolerance and persistence, positioning endoplasmic reticulum stress adaptation as a systems-level resistance mechanism complementary to oncogenic signaling network adaptation
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