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We reported robust relative reductions from baseline (RRFB) in liver fat content (LFC) in a broad population of subjects with nonalcoholic fatty liver disease (NAFLD) in a study of efinopegdutide (EFI), a GLP-1/glucagon receptor coagonist, relative to the selective GLP-1 receptor agonist, semaglutide (SEMA)

The post-translational modifications of GPX4 mainly include succination, ubiquitination and alkylation

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For people from certain ethnic backgrounds, including South Asian, Chinese, Black African or African-Caribbean, the BMI thresholds are lower (typically 27.5 kg/m or greater, or 25 kg/m with comorbidities)