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producing high-avidity binding that substantially exceeds the affinity of monovalent GalNAc ligands and closely mimics the geometry of clinically validated Tri-GalNAc targeting moieties used in approved GalNAc-siRNA therapeutics
Radiostol-d3
Fmoc-Ser(α-Gal-β(1-3)-GalNAc)-OH
in which the sugar hydroxyls are protected as acetate esters
AG124005: β-D-GalNAc-Ethyl-Azide Pack Size:250 mg producing high-avidity binding that substantiallyC10H18N4O6 290. 27 A D N acetylgalactosamine (GalNAc) ligand equipped with an azide functionalized linker through a short ethyl spacer. The terminal azide can be covalently coupled to alkyne partners via copper catalyzed azide alkyne cycloaddition (CuAAC), or to dibenzocyclooctyne (DBCO) and related strained alkynes using copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted
