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132 DTP cells constitute a transient, nongenetic adaptive state that enables a minor tumor cell subpopulation to survive otherwise lethal anticancer therapies and acts as a critical reservoir for resistance evolution within a dynamic balance between state maintenance and exit trajectories (Fig

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For instance, the metabolite hydrogen sulfide (H 2 S), which was produced by Desulfovibrio has been shown to impair GLP-1 expression, thereby disrupting host glucose metabolism (Qi et al., 2024)