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Neuroprotective Research Applications Studies in Journal of Neurochemistry explored DSIPs neuroprotective properties, demonstrating reduced oxidative stress markers in brain tissue, enhanced neuronal survival under stress conditions, improved synaptic function parameters, and protection against excitotoxic injury in research models

Body weight and BMI play a role in determining eligibility for weight management trials, with most retatrutide studies enrolling adults with a BMI of 30 kg/m or above, or 27 kg/m or above in the presence of weight-related comorbidities such as hypertension or dyslipidaemia

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Animal studies have used subcutaneous and intraperitoneal injection