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STEP-1 Trial Data for Semaglutide The STEP-1 trial enrolled 1,961 adults with a BMI of 30 or above, or 27 or above with at least one weight-related comorbidity, and no diabetes
Specifically, pretreatment with the GHSR1a agonist MK-0677 or ghrelin for 30 min resulted in an attenuated response to dopamine, with 60-75% reduction in calcium mobilization
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