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CUR (12.550 mg/kg, p.o., for consecutive 28 days) could notably increase motor nerve conduction velocity (MNCV) and sense nerve conduction velocity (SNCV), as well as repair the injured neurons of the spinal cord in SD rats
These studies will provide the basis for screening compounds affecting Uch-L1 and UBB+1 levels that could improve synaptic and cognitive function in AD patients
To make the immortalized LT2MR cell line used in the luciferase experiments (Fig 3D), LT2M cells were engineered to stably express RAS by retroviral infection with pMSCVHRAS V12 virus
The injury remains sensitive
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