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The results highlight the considerable capability of the DNZ-NLPs to traverse the BBB, a feature that is critical for the development of therapeutic strategies aimed at neurodegenerative disorders such as HD, offering promising implications for the treatment of central nervous system diseases
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In a study using cultured rat hippocampal neurons, pre-treatment of nerve cells with GLP-1 resulted in a weakened Ca 2+ response to glutamate and weakened membrane depolarization (46)
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