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Preclinical Research: Animal studies have demonstrated that GLP-1 agonists can reduce drug-seeking behavior in rodent models of cocaine and opioid addiction
It is also expressed at lower levels in the gut, kidneys, liver, heart, muscle and the PNS (6)
Water retention is another common side effect of stimulating the GH pathway, though its a worthwhile tradeoff compared to the increased strength and energy you experience
However, differences in study subjects and experimental designs, especially the heterogeneity of the gut microbiota itself, have made it difficult to study the modulatory effects of metformin on the gut microbiota
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