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These compelling Phase II findings paved the way for Phase III REDEFINE-1/2 trials, where CagriSema achieved up to ~22.7% weight loss in obesity and ~13.7% in T2DM, while maintaining a consistent safety profile (145)

Whether through medication, surgery, or behavior change, what matters most is tailoring the care plan to each individuals unique biology and needs. The new study received support from the Mayo Clinic Clinical Research Trials Unit, Vivus Inc., and Phenomix Sciences

These studies contribute to understanding melanocortin pathway biology in human populations

More research is needed to optimize protocols