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By 2015, the received wisdom across large-pharma endocrinology was that GCGR antagonism was pharmacologically interesting but pharmacokinetically and pharmacodynamically incompatible with chronic administration
Mice were fed either chow (Altromin #1324, energy density 2.85 kcal/g, Brogaarden, Lynge, Denmark) or a high-fat diet (60% kcal fat, #D12492, energy density 5.21 kcal/g, Ssniff, Soest, Germany) for 35 weeks prior to drug treatment
Zepbound can cause nausea, especially during titration
2015;32(3):e1045
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