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Rotate sites: alternate injection areas to avoid repeated trauma to one spot
They do a lot: regulate insulin secretion stimulate the gallbladder to release bile help with digestion and nutrient absorption keep food moving through and out of the body (known as gut motility) help regulate appetite and satiety (fullness) Some gut peptides you may have heard of: glucagon-like peptide 1 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP) ghrelin (the hunger hormone) Gut peptides like GLP-1 and GIP lower blood sugar levels, which is also known as the incretin effect
In clinical trials such as SURPASS and SURPASS-2, tirzepatide demonstrated comparable or superior efficacy to semaglutide in improving HbA1c and reducing BMI, with weight reductions of 5.4 to 10.5 kg and up to 2.34% HbA1c reduction at 40 weeks.16,17 Tirzepatide is administered as a weekly injection beginning at 2.5 mg weekly and increasing to 5 mg after four weeks
The Swedish Obesity Subjects Study from 2007 evaluated over 4,000 patients in a prospective matched control study and demonstrated improvements in mortality, mostly due to reduction in death from cancer and myocardial infarction, of up to 2030% based on the degree of obesity prior to surgery with sustained outcomes at 1015 years of follow-up [21]
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