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18,19 In chronic tinnitus sufferers for whom this type of improvement or habituation does not occur, it is thought anxiety triggered by tinnitus causes reinforcement of tinnitus perception, leading to more anxiety in a vicious cycle of distress and tinnitus

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The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)

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