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Certain exotoxins, such as toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxins (SEs), act as superantigens that activate large numbers of T cells, resulting in excessive release of pro-inflammatory cytokines including TNF- and IL-6, which cause severe inflammatory damage in mammary tissue
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Weeks 1-4 Starting dose to assess tolerance Weeks 5-8 First dose increase Weeks 9-12 Therapeutic effects begin Weeks 13-16 Approaching target dose Week 17+ Full maintenance dose Side Effects & Safety Most gastrointestinal side effects are mild, temporary, and occur during the dose escalation period
asiatica, H
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