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Neurobiol Dis 2006

Certain medications The following drugs can reduce levels of vitamin B12 in your body: Antibiotics -- long-term use can lower vitamin B levels generally Anti-seizure drugs Chemotherapy medicines, especially methotrexate Drugs used to reduce stomach acid, like H2 blockers (Pepcid AC, Tagamet, Zantac) and proton pump inhibitors (Nexium, Prevacid, Prilosec) Metformin (Glucophage) -- taken for diabetes Colchicine -- taken for gout Some cholesterol-lowering medications Other causes You're over 65

Enhanced Detoxification Your liver relies on methylationa B12-dependent processto detoxify harmful substances from your body

If left untreated, vitamin B12 deficiency can lead to anemia, nerve damage and more, warns Taylor