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In addition to the diffusion and bulk flow theory, other theories have also been proposed, such as the osmoelectric siphon model, which is based on membrane depolarization leading to cell water shedding into the apoplast followed by membrane repolarization and water uptake 43
Nonetheless, low IGF-1 circulating levels are also associated with reduced insulin sensitivity [207], glucose intolerance, and T2D [207, 208, 214]
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