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It is estimated that some 30-50 percent of children and adults in North America, Europe, Australia, New Zealand, and Asia are deficient

The primary side effects are gastrointestinal symptoms including bloating, abdominal discomfort, loose stools, and diarrhoea, particularly at doses exceeding 0.40.5 grams per kilogram of body weight per day

According to the FDA prescribing information for metformin hydrochloride tablets, the drug does not stimulate insulin secretion, which means the risk of low blood sugar (hypoglycemia) is minimal when used alone

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