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Synergistic induction of Apoptosis in acute myelogenous leukemias (AML) by concomitant MAP or Aurora kinase and Mdm2 inhibition of Mdm2, MAP and Aurora Kinases
Biomaterials 142 , 101111 (2017)
The primary site of action of loop diuretics is the Na + /K + /2 Cl cotransporter 2 (NKCC2: encoded by the SLC12A1 gene) which is present in the apical membrane of the epithelial cells in this region of the nephron
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