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When semaglutide binds to GLP-1 receptors in this region, a cascade of neurochemical changes can temporarily destabilize your internal temperature set point, creating sensations of chilliness even in warm environments
This can happen because you might not feel as thirsty, or you could experience nausea and vomiting, which naturally reduces your fluid intake
Once you remove a pen or vial from refrigeration or begin using it, the active window narrows significantly
For eligible patients with severe obesity, bariatric surgery may be considered as per NICE guidelines
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