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(4) Intracellular TAAR1 activation: Elevated cytoplasmic tyramine activates trace amine-associated receptor 1 (TAAR1), promoting signaling pathways that result in phosphorylation of the NET transporter, modify transporter function to cause it to switch to reverse transport mode (rNET)
USC Leonard D
[4] This is not a formal contraindication under UK/EU labelling, but individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN2) are typically excluded from trials pending further data
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