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The clinical trial data are applicable globally, but the eligibility criteria shown are based on UK NICE guidelines
Common gastrointestinal effects are the most frequently reported adverse reactions, with studies reporting variable rates of digestive symptoms: Diarrhoea and loose stools Abdominal cramping and discomfort Constipation (less common) Nausea and bloating These effects are typically dose-dependent and may improve with gradual dose escalation or taking berberine with meals
Retatrutide is being studied for its potential role in supporting appetite regulation, metabolic efficiency, blood sugar balance, and weight management
Binge eating disorder (BED) is more than the occasional episode of overeating
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