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PMID: 20388969 [5] Goldstein AL, Hannappel E, Kleinman HK
Clinical trials frequently show that dosages of 400 to 1,200 mg daily for up to 84 days are comparable in efficacy to standard NSAIDs for reducing the pain and stiffness associated with osteoarthritis, providing a much safer long-term option for patients with sensitive gastrointestinal tracts
As technology advances, so does our ability to address these concerns
Mild to moderate side effects are often observed in the early weeks (~first 6) of medication use and during dose escalation
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