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Aging is accompanied by a range of physiological and neurological changes that can significantly impact cognitive function, including declines in synaptic plasticity (deToledo-Morrell et al., 1988), neurogenesis (Culig et al
This process can be slow and inefficient, and people with absorption problems may take in far less of an oral dose than a healthy person would
Research published in 2011 found that elderly subjects had markedly lower glutathione concentrations compared to younger adults, with 83% higher fractional synthesis rates in young people
Heneka et al., 2025) without any contribution from bone-marrow-derived monocytes to the microglial pool, at least under homeostatic conditions (Masuda et al., 2020), and healthy brain parenchyma has little macrophage and monocyte infiltration due to blood-brain barrier (BBB)
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