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When antioxidant levels are insufficient to keep the free radicals in check, the free radicals start to damage proteins, lipids, and DNA, triggering various illnesses and health conditions, including the following: Lung diseases: Oxidative stress, such as that caused by smoking tobacco products, is related to a number of lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), pulmonary fibrosis, and lung cancer
Kim D, Macconell L, Zhuang D, Kothare PA, Trautmann M, Fineman M et al
In other words, first-pass metabolism describes reduced bioavailability when you consume something orally
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