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This triple-agonist approach enables researchers to study the combined effects of appetite regulation, insulin secretion, and energy expenditure in a single molecule, making it uniquely valuable for obesity models, metabolic syndrome research, and studies exploring synergistic receptor interactions beyond what dual agonists can achieve

For example, MR-Egger estimates for anxiety disorders (OR = 0.81, 95% CI: 0.591.11) and autism (OR = 0.62, 95% CI: 0.321.20) included the null value

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