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It has been used therapeutically for osteoporosis for decades, though its role has diminished somewhat with the advent of more potent antiresorptive agents

Chemosphere 57:10071015 Oliveira EJ, Watson DG (2000) Liquid chromatographymass spectrometry in the study of the metabolism of drugs and other xenobiotics

The relevance of the trans-sulphuration pathway in the survival of cancer cells and reversion of ferroptosis was also proven by silencing CBS, thus inhibiting cysteine synthesis

Through its interaction with NOTCH1, CHAC1/BOTCH inhibits NOTCH1 activity and thereby prevents neuronal stem cell self-renewal (Itoh et al., 2013