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When urine volume drops and frequency decreases, bacteria get more time to adhere to the urethral and bladder walls, multiply, and trigger inflammation
Scrotal hyperthermia, testicular hypoperfusion, and reflux of toxic metabolites enhance the generation of reactive oxygen species (ROS) that can overwhelm the antioxidant capacity of the sperm resulting in the status of oxidative stress (OS)
But stress, medications, aging, and bad health can deplete glutathione levels
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