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Deletion of this gene in mice leads to the decrease in synaptic coverage by astrocytic leaflets, which translates into reduced densities of glutamatergic synapses

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That one C-terminal change has a disproportionate pharmacological consequence, which is why PT-141 and Melanotan II should never be substituted for one another in a protocol

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Gene therapy for diabetic peripheral neuropathy: a randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor

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