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Short-chain acyl-CoA dehydrogenase (SCAD) Mitochondrial Trifunctional Protein (MTP) Deficiency In addition to deficiencies in the fatty acyl-CoA dehydrogenases, that catalyze the first reaction of mitochondrial long-chain fatty acid -oxidation, deficiencies in the activities of the mitochondrial trifunctional protein (MTP), the enzyme complex that catalyzes the last three reactions of mitochondrial long-chain fatty acid -oxidation, have also been identified
Hypoglycemia (the primary acute risk) In the Increlex program, hypoglycemia was reported in 30 of 71 subjects (42%)
PEG-MGF also raises product-specific unknowns, including whether the PEGylated form reaches the intended muscle tissue, how long it remains biologically active, and whether immune responses to PEG or the peptide occur [15]
References: Yakar, S et al., 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton (Jul 2018)
