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Likewise, mutants of pQE30/ PFGRX C32S/C88S were generated with the primers listed in Supplementary Table 10

Based on our summary and analysis of OAs immune mechanisms, many other factors may influence the clinical trial outcomes of biological agents, including the complex etiology of patients, disease duration, the unique immune microenvironment within OA joints, and the critical roles and balance of T cells and B cells in OA

CJC-1295 mimics the action of growth hormone-releasing hormone, prompting the pituitary gland to increase growth hormone production over time