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The Cardioprotective Mechanisms of Natural Products Regulating Nrf2-Associated Cellular Processes in Cardiovascular Diseases Apart from targeting the Nrf2/Keap1 interaction, some cardioprotective natural products were found to regulate Nrf2-associated cellular processes
2301-C E3 UBIQUITIN LIGASE NEDD4 IS A KEY NEGATIVE REGULATOR FOR GSDMD-MEDIATED PYROPTOSIS IN NON-ALCOHOLIC STEATOSIS Rui Jin, Xiaoxiao Wang, Baiyi Liu, Zilong Wang, Yuyun Song, Xiaohe Li, Feng Liu and Huiying Rao, Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis Background: Pyroptosis mediated by GSDMD is thought to be involved in NASH development, but the roles of GSDMD in the pathogenesis of NASH are not fully understood
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In parallel, GSH functions as the principal intracellular antioxidant, directly neutralizing reactive oxygen species and maintaining thioldisulfide homeostasis
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