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Systolic Blood Pressure Went Down 7.4 to 10.6 mmHg in People on Zepbound In the original study, participants who were overweight or obese (meaning they had a body mass index of 27 or greater) taking once-weekly tirzepatide injections of 5 milligrams (mg), 10 mg, or 15 mg for 72 weeks led to average weight reductions of 15 percent, 19.5 percent and 20.9 percent, respectively, compared with placebo

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JAMA 303 , 14101418 (2010)