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In order to define factors that impact delivery efficacy, influences of animal position, body weight and age were investigated [56]

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Its comprehensive mechanism makes it a subject of ongoing neurological scientific research and clinical interest (2)

It could be assumed that a genetic variation of the active renal transporters could have the highest clinical significance and importance for the therapy individualization, as it could be the main genetically variable factor having an impact on metformin exposure [13, 42]