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Polar compounds cannot diffuse across these cell membranes, and the uptake of useful molecules is mediated through transport proteins that specifically select substrates from the extracellular mixture
A 2025 regulatory analysis by Hurley and Frier at Frier Levitt outlined the practical implications: legitimate medical access to many peptides continues, but the sourcing pathway matters more than ever, and the clinician's knowledge of the current regulatory status of each specific compound is a prerequisite for appropriate prescribing
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