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Additionally, while reductions in markers like MDA are reported, direct evidence of decreased oxidative damage to mitochondrial proteins, lipids, and mtDNA is often lacking

In C57BL/6J mice given intravitreal injection of ferric ammonium citrate (FAC), which prompted the accumulation of LPO carboxyethyl pyrrole in RPE cells, these cells died in patches and then expanded at the borders (83)

Hormonal Changes: Potential minor estrogen-related effects, though non-steroidal

In addition, iron chelators have shown beneficial effects in cancer, probably by decreasing mitochondrial energy production and starving the tumors (Frykns et al., 2016)