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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

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We leveraged whole-genome, whole-exome and transcriptome sequencing (Methods) to detect genomic alterations including mutations, copy-number alterations, structural variants (SVs) and gene fusions (Fig