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Additionally, PAI-1 not only acts as a key mediator of TGF--induced senescence but also forms a cascade amplification effect through the activation of the p53-p21-retinoblastoma (Rb) protein signaling axis, ultimately leading to AT2 cell senescence [72, 73]

The metabolism of p -OHA to p -OHNor is well documented and dopamine- hydroxylase present in noradrenergic neurons could easily convert p -OHA to p -OHNor after intraventricular administration

Conventional is anticipated to be the fastest-growing segment during 2026-2033 forecast period, due to its price competitiveness, wide availability, and deeply established supply chains

Yao et al., 2001)