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If you want to start GLP-1 therapy now, Zepbound (tirzepatide) is FDA-approved and produced up to 17.8% weight loss in clinical trials as a dual GLP-1/GIP agonist

Glucagon remains below 0.3% even at 15 mg, ruling out the glucagon-driven liver and heart effects seen with retatrutide. GIPR: the identity receptor At the 2.5 mg starter dose, GIP receptor occupancy is already about 13%

Where GLP-1 therapy may be useful in a brain-health plan For selected patients, GLP-1 therapy may support brain health indirectly by improving the systems that influence cognitive risk

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