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However, because the control beverage elicited similar lipid-lowering effects in hypercholesterolemic participants, and due to the short study duration and small sample size, further research is needed to clarify yerba mates long-term efficacy, optimal dosing, and potential role in populations with chronic conditions such as type 2 diabetes, obesity, or advanced cardiovascular disease

Evidence from two large databases suggests they may be intermediates in mitochondrial fatty acid -oxidation, indicating metabolic inflexibility or mitochondrial dysfunction in both major depression and depressive mood [44, 45]

Results vary for everyone

Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro