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Researchers who maintain a consistent exercise routine while on retatrutide often see their resting heart rate stabilize or even decrease below baseline over months, despite the pharmacological effect pushing it upward

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Lelijveld N, Seal A, Wells JC, Kirkby J, Opondo C, Chimwezi E, Bunn J, Bandsma R, Heyderman RS, Nyirenda MJ, et al

The clinical data puts it on par with retinoids for collagen and wrinkle reduction, without the irritation that drives many people away from prescription retinoids