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Insulin-like Growth Factor (IGF-1 Long-Arginine 3), an 83 amino acid analog of IGF-1, is a highly anabolic hormone released primarily in the liver with the stimulus of growth hormone (HGH)

Similarly, diet-induced obese models demonstrate blunted GH responses to secretagogue stimulation, sometimes requiring 1.52 standard doses to overcome leptin and insulin resistance effects on pituitary sensitivity

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