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The results of in vitro measurements using pQCT and Archimedes principle, in addition to ash weight determinations, show that the increases in cortical and total BMC were due to increased growth of the bones with increased bone dimensions, whereas the volumetric BMD was unchanged. Similarly, Hexarelin led to improved bone mineral content and bone area at the lumbar vertebrae in intact and ovariectomized rats, as shown in a study published in the European Journal of Endocrinology