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This balance between clinical benefit and toxicity risk necessitates careful consideration of dosing strategies, particularly in vulnerable populations
The accelerated approval was granted based on initial overall response rate (ORR) of 57% in 164 treatment-nave patients and duration of response (DOR)40% of responders had a duration of response greater than 12 months, according to the FDAs full approval announcement
[40] Gyaru-o is often written in Japanese as gyaruo ) or 'gal male')
For these patients, I often recommend additional calcium and vitamin D supplementation, weight-bearing exercise 3-4 times per week for at least 30 minutes, and careful monitoring if we decide GLP-1s are appropriate
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