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International Journal of Sport Nutrition and Exercise Metabolism, 2021

Among AOMs, prescribing increased in March 2025 compared to December 2024 (+17.01%)

Surgical Intervention: Cases involving the placement of a gastric pacemaker or other surgeries to aid digestion

however, development for this indication was not pursued to approval Appetite : Preclinical data showing MC4R-dependent anorexigenic effects abolished in MC4R-deficient mice Safety concerns : Reports of nevi darkening and changes in existing moles have raised safety flags that contributed to the compound not progressing to approval MT-2 has been widely used informally as a tanning agent, particularly in Australia, the UK, and Europe, prompting regulatory warnings from multiple health authorities including the TGA and EMA