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Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC expression while inhibition of corticosterone synthesis using metyrapone during hypoxia reverses hypoxia induced downregulation of both Nrf2 and GCLC level
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The DHFR gene is located on chromosome 5q14.1 and is composed of 6 exons that generate three alternatively spliced mRNAs, each of which encode distinct protein isoforms
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